Collectively, the data provide a biological basis for Aβ-induced axonaltransport deficits.
2
Recent studies suggest that axonaltransport of mitochondria along microtubules is disrupted in ALS.
3
Thus, synapsin I does not appear to inhibit the fast axonaltransport mechanism itself.
4
In addition, beta-amyloid precursor protein staining indicated impaired axonaltransport.
5
This enzyme deacetylates microtubules and plays a crucial role in the regulation of axonaltransport.
1
Mice of the WldS strain have normal axoplasmictransport but show an abnormally slow rate of axon and myelin degeneration.
2
In contrast, there was significantly less SP IR observed from nerve of adrenal-transplanted rats, suggesting a diminution of anterograde axoplasmictransport by adrenal transplants.